The mechanism for GLUT4 is an example of a cascade effect, where binding of a ligand to a membrane receptor amplifies the signal and causes a cellular response. In this case, insulin binds to the insulin …

GLUT4 gene, its tissue distribution, and physiological functions Human GLUT4 has 509 amino acid residues and is encoded by SLC2A4 gene in the human genome. It is mainly expressed in …

Jul 30, 2025 · Glucose Transporter Type 4 (GLUT4) is a key protein involved in how cells take up glucose. This transporter acts like a gate, controlling glucose entry into specific cells, thereby helping …

Skeletal muscle both stores glucose as glycogen and oxidizes it to produce energy following the transport step. The principal glucose transporter protein that mediates this uptake is GLUT4, which …

Ana B. Ropero GLUT4 is the major insulin-stimulated glucose transporter and the main rate-limiting step in insulin-stimulated glucose uptake in muscle and adipocytes. GLUT4 expression in the skeletal …

Jun 25, 2024 · In today's health-conscious society, understanding the mechanisms of glucose metabolism and insulin sensitivity is crucial for managing and preventing metabolic disorders. One …

GLUT4, or Glucose Transporter Type 4, is a protein that facilitates the transport of glucose into cells, primarily muscle and fat cells, in response to insulin signaling.

GLUT4 controls glucose transport into fat and muscle tissues in response to insulin and also into muscle during exercise. Thus, investigation of regulated GLUT4 trafficking provides a major means by which …

Aug 24, 2025 · Glucose Transporter Type 4 (GLUT4) is a protein essential for the body’s ability to manage glucose, a primary energy source. It functions as a specialized transporter, moving glucose …

The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) protein in 1988 inspired its molecular cloning in the following year. It also spurred numerous cellular mechanistic studies laying …